Ventolin® inhalation solution

Ventolin® inhalation solution

This product is manufactured by GlaxoSmithKline using the ingredient salbutamol sulphate.

This product is taken via nebulizer.

Why is it prescribed?

Salbutamol is used to relieve and prevent bronchospasm associated with asthma, bronchitis, emphysema and other pulmonary disorders where bronchospasm is a complicating factor. It is also indicated in the prevention of exercise-induced bronchospasm.

  • Ventolin® inhalation solution is meant for inhalation via a nebulizer.
  • Your doctor, pharmacist or health care provider will instruct you on the proper care and use of the nebulizer. It is important to follow the technique outlined by your doctor or pharmacist.
  • Dilution should be done with sterile normal saline.
  • The solution should be stored away from direct sunlight at room temperature (between 15 and 30 degrees centigrade). Do not use if the solution has changed color or becomes cloudy.

Instructions for Use:

1. When preparing the solution for inhalation, use a graduated syringe to draw up VENTOLIN® Respirator Solution from the bottle at the dose directed by your physician. Note: close the VENTOLIN® bottle as soon as the solution is drawn into the syringe. Keep the bottle closed at all times and do not open it unnecessarily. Discard unused, diluted VENTOLIN® Respirator Solution after each use.
2. Inject the solution into the nebulizer through the appropriate opening.
3. Draw into the syringe the amount of diluting fluid (sterile normal saline) directed by your physician and add it to the nebulizer.
1 mL of VENTOLIN® Respirator Solution is usually diluted with 2 to 5 mL of sterile normal saline.
4. Gently shake the nebulizer and connect it with the mouthpiece or face mask.
5. Connect the apparatus to the air pump or oxygen and start the treatment.
6. Breathe calmly and evenly as much as possible until no more mist is formed in the nebulizing chamber. At this point, treatment is finished.
7. Any unused solution in the nebulizer should be discarded.


Alternatives

Other products that have the same ingredient as Ventolin® inhalation solution are •Airomir® MDI •Apo-Salvent MDI •Combivent® Respimat® •Ipratropium/Salbutamol inhalation solution •PMS-Salbutamol Polynebs® •Sanis-Salbutamol Inhaler HFA •Teva-Combo Sterinebs •Teva-Salbutamol HFA •Teva-Salbutamol Sterineb •Ventolin® Diskus® •Ventolin® HFA •

See other products used in the treatment of •asthma •bronchitis •bronchospasm associated with COPD •chronic bronchitis (COPD) •COPD •emphysema (COPD) •exercise-induced bronchospasm •

  • The usual dose for an adult is 2.5 or 5 mg diluted with 2 to 5 mL of sterile normal saline up to 4 times a day if necessary.
  • For children ages 5 to 12 years the average dose is 1.25 or 2.5 mg diluted with 2 to 5 mL of sterile normal saline up to 4 times a day if necessary.

Salbutamol is a short-acting bronchodilator that acts at specific receptors in the body called beta2-adrenergic receptors. Stimulating these beta2-receptors in the bronchial smooth muscle causes the muscle to relax, allowing the bronchial tubes to dilate (widen). Salbutamol relieves the spasm in the small air passages in the lungs and so helps ease breathing problems.


 

Along with its needed effects, salbutamol may cause some unwanted or undesirable effects. Generally, salbutamol is well tolerated and many people will not experience unwanted effects. The severity and duration of these effects are dependant on many factors including duration of therapy, dose, route of administration and individual response. Possible unwanted effects include:

  • cough (inhaled preparations only)
  • nervousness
  • slight palpitations (awareness of heart beat)
  • tremor
  • dry mouth and throat (inhaled preparations only)

Uncommon:

  • headache
  • increased heart rate
  • dizziness
  • nausea
  • muscle cramps
  • trouble sleeping
  • weakness

Rare:

  • restlessness
  • irritability
  • unusual taste
  • angina (chest pain/discomfort)
  • increase in blood pressure
  • hyperactivity in children

Many of these unwanted effects, especially the most common ones, may disappear with continued use. Check with the doctor or pharmacist if any of them continue or become bothersome.

 


Poor response to salbutamol can often be attributed to improper use of the delivery device. Be sure to follow the directions given to you by your pharmacist and read the patient instructions that are provided with each product. Never exceed the maximum dosage set by your physician. If you find that you are not responding to your usual dose, it could mean that your asthma is worsening and you should contact your physician. Increasing the dose, especially over extended periods, can lead to decreasing response to the drug. Keep in mind that the bronchodilator action should last between 2 and 6 hours. If you are using salbutamol for an acute asthma episode and the condition continues or worsens, call your doctor or seek medical attention immediately. If you need to use salbutamol to relieve symptoms more than 3 times a week you should also be using an anti-inflammatory medication (e.g. beclomethasone, fluticasone).

Drug Interactions: Be sure to tell your doctor and pharmacist about any prescription or over-the- counter medications you are taking. The following drugs and drug classes have been known to interact with salbutamol:

  • MAO (monoamine oxidase) inhibitors (e.g. phenelzine, tranylcypromine)
  • tricyclic antidepressants (e.g. amitriptyline)
  • some beta-blockers (e.g. propranolol)
  • other bronchodilators (e.g. terbutaline)
  • digoxin
  • pseudoephedrine

Use is not recommended in the following situations:

  • allergy to salbutamol or any component of the preparation (some of these products may contain sulfite preservatives or lactose so ask your pharmacist).
  • cardiac arrhythmia (irregular heart beat) associated with tachycardia (rapid heart rate)

Caution recommended in the following situations:

  • hyperthyroidism
  • high blood pressure
  • diabetes
  • cardiovascular disorders
  • seizures
  • heart disease
  • low blood potassium
  • sensitivity to sympathomimetics (drugs that stimulate the central nervous sysytem)

Use in pregnancy: Inhaled salbutamol is considered compatible with pregnancy.  Consult your doctor or pharmacist if you suspect that you may be pregnant.
Use while breastfeeding: Inhaled salbutamol is considered compatible with breastfeeding, however, consult your doctor or pharmacist before use.