Tezspire™
This product is manufactured by AstraZeneca Canada Inc. using the ingredient tezepelumab.
This product is taken via subcutaneous injection.
Why is it prescribed?
Tezepelumab is used on a regular basis to treat severe asthma in people 12 years of age and older. It is used with other asthma medicines when those medicines are not adequately controlling asthma symptoms.
Read the instructions for use carefully and discuss use with your healthcare provider so that you are comfortable giving yourself the injections.
Do not share or use the pre-filled syringe or pre-filled pen more than one time.
Do not stop using this medication without speaking to your healthcare professional first. Interrupting or stopping it may cause your asthma symptoms and attacks to return.
Tezspire™ typically starts working after about 2 weeks, but your symptoms may continue to improve for several months.
Store in the refrigerator (2°C to 8°C) in the original package. It may be kept at room temperature (20˚C to 25˚C) in the original carton for a
maximum of 30 days. Once it has reached room temperature, do not put it back in the refrigerator. Throw away any that has been stored at room temperature after 30 days.
Alternatives
See other products used in the treatment of •asthma •
The recommended dose for adults and adolescents 12 years of age and older is 210 mg given by subcutaneous injection every 4 weeks
Tezepelumab works by blocking a protein involved in immune and allergic responses that cause airway inflammation. This protein is called thymic stromal lymphopoietin (TSLP). By blocking TSLP, tezepelumab reduces levels of certain proteins and cells that cause airway inflammation.
More common:
- Sore throat
- Redness, swelling, and pain at injection site
- joint pain
- rash
Tezepelum may cause allergic reactions. Symptoms of a mild allergic reaction can include:
- skin rash
- itchiness
- flushing
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to tezepelumab, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Remember that this medication is not a rescue medicine and should not be used to treat a sudden asthma attack. If you have a sudden asthma flare-up, you should use your rescue medication as prescribed by your doctor.
Do not use if you’ve had an allergic reaction to tezepelumab or any of the ingredients in this product.
Do not use this medication if you have a parasitic infection as tezepelumab may weaken your ability to fight off these types of infections.
Drug Interactions:
- at this time there are no known interactions with tezepelumab
Use in pregnancy: At this time, it is not known how tezepelumab affects pregnancy. Discuss use with your health care provider
Use in breastfeeding: Tezepelumab does pass into breastmilk. Discuss use with your health care provider